1. Andropause: The Elephant in the Room
“Andropause,” often called “male menopause,” is not a marketing term or a buzzword. It is a highly accurate description of a condition marked and exacerbated by a slow but steady decline in endogenous testosterone production. Low testosterone levels give rise to several quality of life issues, including:
- reduced muscle bulk/strength
- low mood/depression
- fewer spontaneous erections
- loss of libido
- decreased ability to concentrate
- increased body fat
The difference between andropause and menopause is that the former is characterized by gradual declines in hormone levels, while in women, hormone levels drop suddenly. Healthy men will usually experience a 1% drop in testosterone every year starting around age 40. Young men typically have testosterone levels of approximately 1,000 ng/dl, while the average level for an 80-year-old man is about 200 ng/dl. Referring back to the testosterone saliva test in the previous chapter, the starting ng/dl levels of men in various age brackets are about normal. The oldest volunteer, age 52, achieved a 70% increase in testosterone after LJ100® consumption, peaking at 765 ng/dl at the study’s conclusion.
Researchers George and Henkel explain in their January 2014 paper published in Andrologia, “Testosterone deficiency syndrome (TDS) is characterized by numerous symptoms, including low libido, increased fat mass, fatigue, erectile dysfunction or osteoporosis, and up to 80% of men will experience some kind of ageing males’ symptoms. This is caused by the age-depending decline in serum testosterone levels with concentrations being about 40–50% lower in men older than 60 years compared with young men. This significant decline in testosterone levels is further closely linked with medical conditions such as obesity, metabolic syndrome, diabetes or hypertension. The conventional way of treating TDS is the testosterone replacement therapy (TRT), for which preparations are on the market. Apart from the beneficial effects of TRT, significant adverse side effects have been described, and prostate cancer (PCa) as absolute contraindication is debated” (12).
They add that LJ100® is a “natural alternative to TRT and has been shown to restore serum testosterone levels, thus significantly improving sexual health. This includes significant positive effects on bone health and physical condition of patients. In addition, a significant antihyperglycemic effect and cytotoxicity against PCas cells has been shown. Thus far, at therapeutic concentrations, no significant side effects of the treatment were obvious. Therefore, TA might be a safe alternative to TRT” (12).
Late-onset hypogonadism (LOH) is defined by reduced serum testosterone levels (either total testosterone or free testosterone). For many older men, this status can cause detrimental physiological issues, as well as depression. One study published in the First International Journal of Andrologia (2011) investigated the effects of LJ100® in this population (13).
In the study, 76 men with LOH were given 200 mg of LJ100® for one month. LJ100® significantly improved AMS scores. AMS scores improved from 10.5% at the study’s onset to 70.1% at its conclusion. Serum testosterone rose from 5.66 nm to 8.31 nm (46.82% increase). The percentage of men with testosterone levels in normal ranges at the study’s beginning was 35.5%; this increased to 90.8% after one month of daily LJ100® supplementation. Thus, LJ100® appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism.
In a 2002 study presented at the First Asian Andrology Forum in Shanghai, China, 30 male patients took 100 mg of LJ100® for three weeks; Partial Androgen Deficiency In Aging Men (PADAM) scores improved by 82%, suggesting significant improvement in physical, vasomotor, psychological and sexual wellbeing. DHEA increased from 26% to 47%, SHBG decreased from 36% to 66% of subjects. Consequently, free testosterone levels increased from 39% to 73% in the LJ100® group (1).
In another study published in the International Journal of Andrology (2005), 20 male volunteers of various health conditions from the ages of 38 to 58 were randomly given either 200, 400, 600 mg of LJ100® or placebo for two months. The LJ100® group showed improvement in Sexual Health Inventory for Men, improvement in sexual desires and performance. Aging Males’ Score also showed improvement in sexual, physical, psychology and vasomotor domain. Testosterone and DHEA levels showed high normal levels when compared to baseline. In addition, LJ100® group were found to have high normal level of IGF-1 compared to placebo (17).
2. LJ100® as a Potential Natural Energizer for Healthy Aging in Men.
M.I.M. Tambi, S. Othman AND J.M. Saad. Published: First Asian Andrology 2002
This study investigated the effect of LJ100® on the testosterone hormone, dehydroepiandrosterone sulphate (DHEA) and sex hormone binding globulin (SHBG) levels in human, as well as the Quality of Life (QOL) of subjects through PADAM score and Sexual Health Inventory Questionnaires (SHIQ). 30 men, aged between 31-52 years old were recruited in a randomized open trial. Subjects were supplied with 100mg of LJ100® for 3 weeks. SHIQ showed 62% of the subjects had increase or maximum score, with increased sexual desire and the success in the attempts at sexual intercourse. PADAM Score improve in 82% of the subjects, 91% improvement in physical component, 82% improvement in psychological component, and 50% improvement in vasomotor score. Analysis of DHEA showed gradual increase in the level to 47% after 3 weeks, suggesting LJ100 may influence DHEA production, which would in turn be aromatized to testosterone. SHBG analysis reduced in 66% of subjects after 3 weeks. Consequently, when SHBG declines, free testosterone index (FTI) goes up in 73% of the subjects.
The-following responses were received:
3. LJ100 as testosterone booster for managing men with late-onset hypogonadism
M. I. B. M. Tambi1,2, M. K. Imran2 & R. R. Henkel3
Published: First International Journal of Angrologia 2011
76 patients suffering from late-onset hypogonadism (LOH) were given 200 mg of LJ100 for 1 month. LJ100 significantly (P < 0.0001) improved the Aging Male Symptom (AMS) score as well as the serum testosterone concentration. Before treatment only 10.5% of the patients did not show any complaint according to the AMS scale and 35.5% had normal testosterone levels, after the completed treatment 71.7% and 90.8% of the patients showed normal values, respectively. Serum testosterone raise from 5.66 nm to 8.31 nm (46.82% increase). Thus, LJ100 appears to be useful as a supplement in overcoming the symptoms of LOH and for the management of hypogonadism.
4. LJ100, a Potent Adaptogen, Maintains Healthy Aging in Men
Tambi, M.I. Kadir, A.B.
Published: International Journal of Andrology (2005). Vol. 28(Suppl 1):25-44.
Published: Asian Journal of Andrology, Oct 2006, 0154 (448)
Published: The Aging Male (2007). F11-Pg 92
20 male volunteers of various health conditions from the ages of 38 to 58 were randomly given either 200,400,600 mg of LJ100® (22% Bioactive Eurypeptides) or placebo for 2 months.
- Majority of volunteers showed improvement in Sexual Health Inventory for Man, improvement in sexual desires and performance.
- Aging Male Score showed improvement in LJ100 group compared to placebo, showing improvement in sexual, physical, psychology, and vasomotor domain.
- Testosterone and DHEAS levels showed high normal levels when compared to baseline.
- Improvement in HDL Cholesterol.
- Volunteers who had type 2 diabetes showed improvement in blood glucose levels.
- LJ100® (22% Bioactive Eurypeptides) group were found to have high normal level of IGF-1.
- Majority of volunteers on LJ100® have high normal level of thyroxin compared to placebo
- Profiles of vital body functions: blood profile, lipid profile (including triglycerides and cholesterol), liver function, renal function, electrolytes, various tumor markers including PSA were all within normal range.
5. Immunomodulation in Middle-Aged Humans
Immunomodulation in Middle-Aged Humans Via the Ingestion of LJ100/Physta® Standardized Root Water Extract of Eurycoma longifolia Jack —A Randomized, Double-Blind, Placebo-Controlled, Parallel Study
This study was aimed to investigate the capacity of a standardized root water extract of Eurycoma longifolia (Tongkat Ali, TA), LJ100/Physta® to modulate human immunity in a middle-aged Japanese population. This randomized, double-blind, placebo-controlled, parallel study was conducted for 4 weeks. Eighty-four of 126 subjects had relatively lower scores according to Scoring of Immunological Vigor (SIV) screening. Subjects were instructed to ingest either 200 mg/day of TA or rice powder as a placebo for 4 weeks [TA and Placebo (P) groups] and to visit a clinic in Tokyo twice (weeks 0 and 4). SIV, immunological grade, immunological age, and other immune param-eters were measured. Eighty-three subjects completed the study; 40 in the TA group and 41 in the P group were statistically analyzed, whereas two were excluded from the analyses. At week 4, the SIV and immunological grade were significantly higher in the TA group than those in P group (p < 0.05). The numbers of total, naïve, and CD4+ T cells were also higher in the TA group than those in P group (p < 0.05). No severe adverse events were observed. The results suggest that ingestion of the root water extract of TA (LJ100/Physta®) enhances comprehensive immunity in both middle-aged men and women. This study is registered in UMIN-CTR (UMIN000011753).
6. Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors—A Pilot Study
Tongkat Ali (Eurycoma longifolia; TA) is known to increase testosterone levels and alleviate aging males’ symptoms. This study aimed at investigating TA as an ergogenic supplement for elderly people. Thirteen physically active male and 12 physically active female seniors (57–72 years) were supplemented with 400-mg TA extract daily for 5 weeks. Standard hematological parameters were taken. In addition, the concentrations of total and free testosterone, dihydroepiandrosterone, cortisol, insulin-like growth factor-1, and sex hormone-binding globulin were analyzed. As additional biochemical parameters, blood urea nitrogen and creatine kinase as parameters of kidney function and muscle damage, respectively, as well as the muscle strength by a simple handgrip test were determined. After treatment, hemoglobin, testosterone, and dihydroepiandrosterone concentrations, and the ratio of total testosterone/cortisol and muscle force remained significantly lower in female seniors than in male seniors. Hematocrit and erythrocyte count in male seniors increased slightly but were significantly higher than in female seniors. Treatment resulted in significant increases in total and free testosterone concentrations and muscular force in men and women. The increase in free testosterone in women is thought to be due to the significant decline in sex hormone-binding globulin concentrations. The study affirms the ergogenic benefit of TA through enhanced muscle strength.
7. Phytoandrogenic Properties of Eurycoma longifolia as Natural
Alternative to Testosterone Replacement Therapy
George A, Henkel R
Published: Andrologia. Jan 2014
The testosterone deficiency syndrome (TDS) is characterised by numerous symptoms, including low libido, increased fat mass, fatigue, erectile dysfunction or osteoporosis, and up to 80% of men will experience some kind of ageing males’ symptoms. This is caused by the age-depending decline in serum testosterone levels with concentrations being about 40-50% lower in men older than 60 years compared with young men. This significant decline in testosterone levels is further closely linked with medical conditions such as obesity, metabolic syndrome, diabetes or hypertension. The conventional way of treating TDS is the testosterone replacement therapy (TRT), for which preparations are on the market. Apart from the beneficial effects of TRT, significant adverse side effects have been described, and prostate cancer (PCa) as absolute contraindication is debated. Eurycoma longifolia (Tongkat Ali; TA) is natural alternative to TRT and has been shown to restore serum testosterone levels, thus significantly improving sexual health. This includes significant positive effects on bone health and physical condition of patients. In addition, a significant antihyperglycaemic effect and cytotoxicity against PCas cells has been shown. Thus far, at therapeutic concentrations, no significant side effects of the treatment were obvious. Therefore, TA might be a safe alternative to TRT.